tag:blogger.com,1999:blog-6146376483374589779.post6076336402891439675..comments2024-02-14T11:18:50.296-08:00Comments on Wiring the Brain: Why have genetic linkage studies of schizophrenia failed?Kevin Mitchellhttp://www.blogger.com/profile/07172255754953214162noreply@blogger.comBlogger11125tag:blogger.com,1999:blog-6146376483374589779.post-82626890541256628672014-05-04T05:39:50.848-07:002014-05-04T05:39:50.848-07:00I totally love this site! All of your posts make m...I totally love this site! All of your posts make me smile! You had a great example this is apply to manifesting a relationship <br /><a href="http://www.healthybodyinc.com/garcinia-cambogia-extreme-with-75-hca-180-count/" rel="nofollow">Healthy body INC</a>steve7876https://www.blogger.com/profile/09364215276730874421noreply@blogger.comtag:blogger.com,1999:blog-6146376483374589779.post-22655708750596634632013-12-27T05:22:08.636-08:002013-12-27T05:22:08.636-08:00Hope there would more twin studies for schizophre...Hope there would more twin studies for schizophrenia and we would manage at last to find the specific genetic differences involved that has been the tricky bit! Thanks a lot Kevin for the efforts.<a href="http://onlinecasino770.eu/" rel="nofollow">Kevin Right</a>Anonymoushttps://www.blogger.com/profile/06832152365704055925noreply@blogger.comtag:blogger.com,1999:blog-6146376483374589779.post-44528297781211946432013-03-22T14:49:38.860-07:002013-03-22T14:49:38.860-07:00There is definitely so many people dealing with th...There is definitely so many people dealing with this so much here. So much more research has to be done done with it. I hope we can get a resolution to this here. <br /><a href="http://www.geebeauty.com/toronto.php?page=Skin-Tightening" rel="nofollow">click here</a>gamefan12https://www.blogger.com/profile/17700305176595632282noreply@blogger.comtag:blogger.com,1999:blog-6146376483374589779.post-34634644092892600132012-09-10T00:31:15.192-07:002012-09-10T00:31:15.192-07:00Very informative stuff! thanks for sharing the blo...Very informative stuff! thanks for sharing the blog.I wish you to post the new updates regularly.<br /><br /><a href="http://keywordjump.com/" rel="nofollow">best seo services</a>Anonymoushttps://www.blogger.com/profile/16195515793064239068noreply@blogger.comtag:blogger.com,1999:blog-6146376483374589779.post-65855982077794478182012-09-06T01:34:52.819-07:002012-09-06T01:34:52.819-07:00Thanks, I really appreciate the positive feedback ...Thanks, I really appreciate the positive feedback and also your sharing your personal experience. Kevin Mitchellhttps://www.blogger.com/profile/07172255754953214162noreply@blogger.comtag:blogger.com,1999:blog-6146376483374589779.post-12827435776689837722012-09-05T10:46:16.570-07:002012-09-05T10:46:16.570-07:00Thanks very much for making this information avail...Thanks very much for making this information available. I love reading stuff like this as it helps me understand the causes of my condition better, although I have no scientific knowledge so a lot of the information out there is difficult for me to understand. Thank you for making this so accessable.<br />I've always felt, from my own experience, that genes are the main cause of schizophrenia. I believe this because I have suffered for my entire life, and there are so many instances of mental illness in my family. I believe that one day science will find the cause of the problem, and we will be on the way to finding an effective treatment. Keep up the good work! EmilyAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-6146376483374589779.post-84014790582550338622012-08-30T20:30:30.302-07:002012-08-30T20:30:30.302-07:00I would say that 3 decades of failed genetic linka...I would say that 3 decades of failed genetic linkage studies should at least raise the question of whether genes have anything to do with schizophrenia. Each time a new genetic linkage study comes out, it is often front page news that "gene for schizophrenia" has been found. We already know that no such gene exists and it is getting harder and harder to make the case ever for a miniscule association between a genetic loci and schizophrenia. We have had 30 years of false positives. These studies are poorly designed, generally without a control, and are replete with false positives that are never replicated. It's not just schizophrenia. The same can be said for any mental disorder. Not one gene has been definitively linked to any mental disorder to date. It may be paradoxical, but it is time to consider the possibility that these disorders are not related to genes. True, heritability has generally been demonstrated, but heritability does not prove that it is genetic. Feel free to check my new blog out for some discussion of specific genetic linkage studies. It is a work in progress, but I have a few posts: www.genesareoverrated.blogspot.comStevehttps://www.blogger.com/profile/01910595180093275632noreply@blogger.comtag:blogger.com,1999:blog-6146376483374589779.post-86447287230155814802012-08-23T01:25:58.990-07:002012-08-23T01:25:58.990-07:00Thanks Guy for that perspective. I think you have ...Thanks Guy for that perspective. I think you have hit the nail on the head. Right now we diagnose schizophrenia based on a person's behaviour and reports of their subjective experience, which point to a recognisable cluster of symptoms with a characteristic progression, which we label as schizophrenia. But this is clinically very heterogeneous and we know it is also etiologically very heterogeneous - it could be arrived at through many different routes. Currently, we know very little of what those routes might be, but accepting the heterogeneity is key to making progress.Kevin Mitchellhttps://www.blogger.com/profile/07172255754953214162noreply@blogger.comtag:blogger.com,1999:blog-6146376483374589779.post-77852021678733105512012-08-22T09:57:54.696-07:002012-08-22T09:57:54.696-07:00Thanks for a very informative explanation.
I think...Thanks for a very informative explanation.<br />I think that some lessons should be taken from hearing loss. <br />The complex heritabilty of hearing loss might be a good model to the neurodevelopmental\psychiatric disorders.<br /><br />But a more important lesson is the phenotype. In the past deaf people were considered deaf&dumb. In fact, deaf people became mentally retarded as a result of their social isolation. Preventing isolation by simply teaching deaf people to communicate prevented their mental retardation. A good reading about it is Seeing Voices by Oliver Sacks.<br />the lesson is that to understand the genetics of hearing loss the hearing should be studied not the mental retardation.<br />What I am trying to say is that although some psychiatric disorders are heritable, they are also acquired. <br />In order to understand their etiology we need to distinguish between the innate and the acquired phenotypes. Guyhttps://www.blogger.com/profile/17242527831298435835noreply@blogger.comtag:blogger.com,1999:blog-6146376483374589779.post-76354911423310975932012-08-22T06:12:32.314-07:002012-08-22T06:12:32.314-07:00Thanks for your comment. Regarding your first poin...Thanks for your comment. Regarding your first point, see also this recent post: http://wiringthebrain.blogspot.ie/2012/08/are-human-brains-especially-fragile.html<br /><br />As for why we are looking for something genetic, the reason is that family and twin studies show that schizophrenia is very highly heritable - that is, some people are more prone to it than others and the reason is largely genetic. So, there's something to explain - it's finding the specific genetic differences involved that has been the tricky bit!Kevin Mitchellhttps://www.blogger.com/profile/07172255754953214162noreply@blogger.comtag:blogger.com,1999:blog-6146376483374589779.post-36768876729632088262012-08-22T06:07:25.471-07:002012-08-22T06:07:25.471-07:00maybe being human is what genetically puts you at ...maybe being human is what genetically puts you at risk of schizophrenia<br /><br />:-)<br /><br />or maybe you are looking for something where you should be looking for nothing<br /><br />perhaps it is epigenetic<br /><br />and we are all at risk given the right (ie wrong) environmental conditions <br /><br />but please do continue<br /><br />p<br />The Peak Oil Poethttps://www.blogger.com/profile/16689230374176801643noreply@blogger.com