tag:blogger.com,1999:blog-6146376483374589779.post77389752621454475..comments2024-02-14T11:18:50.296-08:00Comments on Wiring the Brain: On genetic causality: forwards and backwardsKevin Mitchellhttp://www.blogger.com/profile/07172255754953214162noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-6146376483374589779.post-19146347265952463362014-05-29T05:34:19.152-07:002014-05-29T05:34:19.152-07:00This comment has been removed by the author.Anonymoushttps://www.blogger.com/profile/05903779927169909681noreply@blogger.comtag:blogger.com,1999:blog-6146376483374589779.post-48808166586590965162014-05-15T05:13:36.666-07:002014-05-15T05:13:36.666-07:00We make sure students get quality writing services...We make sure students get quality writing services online and <a href="http://www.poweredessays.com/" rel="nofollow">essays online</a> available for students. We are providing services in London. Sadiahttps://www.blogger.com/profile/13452823552545627692noreply@blogger.comtag:blogger.com,1999:blog-6146376483374589779.post-80470285146409510282014-02-09T17:35:41.238-08:002014-02-09T17:35:41.238-08:00I just want to thank you for this wonderful blog. ...I just want to thank you for this wonderful blog. As an undergraduate student in psychology (with a background in philosophy) I appreciate the approach to psychology this blog represents - that is an approach that exists across the levels of explanation. By making genetics accessible you have changed the way I think about psychology and the brain improving how I approach topics. Moreover, your articles are just thoroughly enjoyable to read. Thanks again. Anonymoushttps://www.blogger.com/profile/10258853787585756555noreply@blogger.comtag:blogger.com,1999:blog-6146376483374589779.post-30822689778884063322014-01-07T23:56:13.484-08:002014-01-07T23:56:13.484-08:00Yes, I agree. The post deals with cases where we d...Yes, I agree. The post deals with cases where we do find some reasonably penetrant mutation. (But does illustrate that even ones with fairly low penetrance can be informative in patients with an otherwise rare disease). Of course, in many cases we may not find any such allele, and it certainly may not always be the case that there is a single, "primary" mutation. My own view on complex disorders is that they are indeed complex, but not in the way that many people have thought. See here, What is Complex about Complex Disorders? http://genomebiology.com/2012/13/1/237/Kevin Mitchellhttps://www.blogger.com/profile/07172255754953214162noreply@blogger.comtag:blogger.com,1999:blog-6146376483374589779.post-36029308369858435972014-01-07T14:16:38.272-08:002014-01-07T14:16:38.272-08:00Nice post, Kevin. We agree with you that genetics...Nice post, Kevin. We agree with you that genetics is getting more complicated. Though, as we said the other day in a post, while Mendelian diseases have gotten more complex, people too often treat complex diseases as though they should be simple. And, yes, asking whether an individual will get a particular disease given a particular genotype can be very different from asking why an individual has a particular set of symptoms. Both questions are sometimes answerable, but for only a subset of alleles and diseases, usually rare and often applicable to multiply affected families. The second is unlikely ever to be answerable for diseases that involve a strong environmental component.Anne Buchananhttps://www.blogger.com/profile/09212151396672651221noreply@blogger.com