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Showing posts from February, 2018

Lessons for human genetics from genetic screens in model organisms

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Why did the axon cross the midline? That seems like a simple enough biological problem to solve. In the developing nervous system, especially in the anatomically simple spinal cord, some nerve cells send a slender nerve fibre (called an axon) across the midline of the nervous system to connect to cells on the other side. The projections of other neurons are restricted to the same side as their own cell bodies. The connections between the two sides are crucial in coordinating movement of the two sides of the body. But, more importantly for this discussion, this system is simple enough to be genetically tractable – at least it seems so.
When I arrived as a graduate student in the lab of Corey Goodman at the University of California at Berkeley, his group had just carried out a genetic screen in fruit flies to try and understand how this developmental decision was controlled. Flies have an equivalent of a spinal cord, called the ventral nerve cord, and Corey and his colleagues had spent m…

Panpsychism – not even wrong. Or is it?

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