Apologies for not posting anything recently. I have something in the works at BigThink and a few more in the pipeline but it has been hard finding the time to blog recently. I hope to be back to it in a couple of weeks.
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When living creatures perceive something, they’re concerned with two questions: What is it? and: What should I do about it ? You might think that the machinery for answering those questions evolved in that order – like you’d have to know what something is before you can know what to do about it – but it seems likely to have been the opposite. The actions of the simplest creatures when faced with various stimuli in the world are mostly coordinated by pragmatic couplings – signals that are prescriptive rather than descriptive . But these mechanisms laid the foundation for the evolution of decoupled internal representations with true semantic content. For living organisms to go on persisting – which, let’s face it, is their whole schtick – they have to take in energy and raw materials (food, oxygen) and use them to keep their internal economy humming. Many organisms manage this process – known as homeostasis – by staying put and letting resources come to them. The problem with this
As many as a quarter of people will experience mental illness at some point in their life ( over a third in any given year with more expansive definitions). At least 5% of the population suffer from lifelong brain-based disorders, including intellectual disability, autism spectrum disorders, schizophrenia, epilepsy and many others. Many of these conditions dramatically increase mortality rates and reduce fecundity (number of offspring), impacting heavily on evolutionary fitness. Faced with these numbers, we have to ask the question: are human brains especially fragile? Are we different from other species in this regard? Is the brain different from other organs? As all of the disorders listed above are highly heritable, these questions can be framed from a genetic perspective: is there something about the genetic program of human brain development that makes it especially sensitive to the effects of mutations? I have written lately about the robustnes
Can molecular memories of our ancestors’ experiences affect our own behaviour and physiology? That idea has certainly grabbed hold of the public imagination, under the banner of the seemingly ubiquitous buzzword “epigenetics”. Transgenerational epigenetic inheritance is the idea that a person’s experiences can somehow mark their genomes in ways that are passed on to their children and grandchildren. Those marks on the genome are then thought to influence gene expression and affect the behaviour and physiology of people who inherit them. The way this notion is referred to – both in popular pieces and in the scientific literature – you’d be forgiven for thinking it is an established fact in humans, based on mountains of consistent, compelling evidence. In fact, the opposite is true – it is based on the flimsiest of evidence from a very small number of studies with very small sample sizes and serious methodological flaws. [Note that there is, by contras
Looking forward to seeing your BigThoughts :)
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