Apologies for not posting anything recently. I have something in the works at BigThink and a few more in the pipeline but it has been hard finding the time to blog recently. I hope to be back to it in a couple of weeks.
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Can molecular memories of our ancestors’ experiences affect our own behaviour and physiology? That idea has certainly grabbed hold of the public imagination, under the banner of the seemingly ubiquitous buzzword “epigenetics”. Transgenerational epigenetic inheritance is the idea that a person’s experiences can somehow mark their genomes in ways that are passed on to their children and grandchildren. Those marks on the genome are then thought to influence gene expression and affect the behaviour and physiology of people who inherit them. The way this notion is referred to – both in popular pieces and in the scientific literature – you’d be forgiven for thinking it is an established fact in humans, based on mountains of consistent, compelling evidence. In fact, the opposite is true – it is based on the flimsiest of evidence from a very small number of studies with very small sample sizes and serious methodological flaws. [Note that there is, by contras
I’ve been reading this excellent paper by David Barack and John Krakauer, on “ Two Views on the Cognitive Brain ”, and it made me wonder about which mode of nervous system function might have come first. To use their terminology, the “Sherringtonian” view (named after Charles Scott Sherrington ) focuses on individual neurons as the elementary units of control, computation, and cognition. In this view, neurons can be thought of as individual relays in a control circuit (such as a reflex) or as elements performing discrete logical operations, which can be combined into larger circuits to carry out more complex computations. It’s all very bottom-up, algorithmic, and mechanistic (and, indeed, provided the inspiration for artificial neuronal networks, as conceived by McCulloch and Pitts ). The “Hopfieldian” view (after John Hopfield ), by contrast, takes the view that more global and dynamic patterns of activity across populations of neurons are the elements encoding and representing cogni
It seems an innocent enough question: why are males more frequently left-handed than females? But the answer is far from simple, and it reveals fundamental principles of how our psychological and behavioural traits are encoded in our genomes, how variability in those traits arise, and how development is channelled towards specific outcomes. It turns out that the explanation rests on an underlying difference between males and females that has far-reaching consequences for all kinds of traits, including neurodevelopmental disorders. Pixabay.com A recent tweet from Abdel Abdellaoui showed data on rates of left-handedness obtained from the UK Biobank, and asked two questions: why is left-handedness more common in males and why are rates of reported left-handedness increasing over time? I don’t think the answer to the second question is known but I presume it has to do with the declining practice of forcing left-handers to write right-handed. This once common practice reflects a lon
Looking forward to seeing your BigThoughts :)
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